Figure 3
From: Facilitation of Cardiac Vagal Activity by CRF-R1 Antagonists during Swim Stress in Rats
Changes in heart rate (a) and PR interval (b) among vehicle-treated (n=12) and 3.2 mg/kg methylatropine nitrate (mATR; n=9) treated rats during swim exposure. Of vehicle treated rats, 6/12 sank whereas 0/9 mATR-treated rats sank. Baseline (BL) HR and PR interval were collected following vehicle or drug treatment while each rat was in its homecage, BL data reported was collected just prior to the swim stress. Rats were placed in the swim tank at time zero and recorded until sinking or 2 h. ↑ indicate when each vehicle-treated rat sank.
