Abstract
Exposure of hamster cells to large doses of polyoma virus is known to result in permanent transformation of a small proportion of cells. Experiments with cells in suspension now suggest that a much higher proportion of infected cells undergoes a temporary change, in which at least one characteristic of transformation is acquired for a few cell divisions and then lost again. This suggests that acquisition of the transformed phenotypes does not depend upon stable integration of the viral genome.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
199,00 € per year
only 3,90 € per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Stoker, M., and Macpherson, I., Virology, 14, 359 (1961).
Sachs, L., Medina, D., and Berwald, Y., Virology, 17, 491 (1962).
Macpherson, I., and Montagnier, L., Virology, 23, 291 (1964).
Macpherson, I., and Stoker, M., Virology, 16, 147 (1962).
Diamond, L., Intern. J. Cancer, 2, 143 (1967).
Todaro, G. J., and Green, H., Virology, 28, 756 (1966).
Black, P. H., Virology, 28, 760 (1966).
Crawford, L. V., Virology, 18, 177 (1962).
Crawford, L. V., Crawford, E. M., and Watson, D. H., Virology, 18, 170 (1962).
Abel, P., and Crawford, L. V., Virology, 19, 470 (1963).
Winocour, E., Virology, 31, 15 (1967).
Michel, M. R., Hirt, B., and Weil, R., Proc. US Nat. Acad. Sci., 58, 1381 (1967).
Meyer, G., Lherisson, A.-M., and Bonneau, H., Bull. Cancer, Paris, 54/1, 79 (1967).
Sachs, L., in Tumour Viruses of Murine Origin, Ciba Symposium, 1962 (edit. by Wolstenholme, G. E. W., and O'Connor, M.), 380 and discussion 392–3 (Churchill Ltd., London).
Dulbecco, R., Hartwell, L. H., and Vogt, M., Proc. US Nat. Acad. Sci., 53, 403 (1964).
Gershon, D., Sachs, L., and Winocour, E., Proc. US Nat. Acad. Sci., 56, 918 (1966).
Sauer, G., and Defendi, V., Proc. US Nat. Acad. Sci., 56, 452 (1966).
Macpherson, I. A., in Wistar Inst. Bienn. Res. Rep. 1962–1963, 52.
Black, P. H., and Rowe, W. P., Proc. US Nat. Acad. Sci., 54, 1126 (1965).
Hartwell, L. H., Vogt, M., and Dulbecco, R., Virology, 27, 262 (1965).
Fraser, K. B., and Gharpure, M., Virology, 18, 505 (1962).
Thomas, R., in The Molecular Biology of Viruses, Society of General Microbiology Symposium, 1968 (edit. by Crawford, L. V., and Stoker M. G. P.), 315.
Uetake, H., Luria, S. E., and Burrous, J. W., Virology, 5, 68 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
STOKER, M. Abortive Transformation by Polyoma Virus. Nature 218, 234–238 (1968). https://doi.org/10.1038/218234a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/218234a0
This article is cited by
-
The N-terminal common ___domain of simian virus 40 large T and small t antigens acts as a transformation suppressor of the HER-2/neu oncogene
Oncogene (2000)
-
A model for tumorigenicity and metastatic potential: Growth in 1.0% agar cultures
In Vitro Cellular & Developmental Biology (1987)
-
Anchorage-independent growth of normal human mesothelial cells: A sensitive bioassay for EGF which discloses the absence of this factor in fetal calf serum
In Vitro Cellular & Developmental Biology (1985)
-
Intercellular communication and the control of growth: XII. Alteration of junctional permeability by simian virus 40. roles of the large and smallT antigens
The Journal of Membrane Biology (1984)
-
Growth factors adherent to cell substrate are mitogenically active in situ
Nature (1982)
