FIGURE 4 | Modern Pathology

FIGURE 4

From: MAL Expression in Lymphoid Cells: Further Evidence for MAL as a Distinct Molecular Marker of Primary Mediastinal Large B-Cell Lymphomas

FIGURE 4

MAL protein expression in lymphoid malignancies. A, primary mediastinal large B-cell lymphoma stained for MAL showing membranous and occasionally paranuclear dotlike positivity (arrow) of virtually all tumor cells. B, primary mediastinal large B-cell lymphoma–derived B-cell line MedB-1 stained for MAL, showing positive tumor cells. C, nonmediastinal diffuse large B-cell lymphoma stained for MAL, showing that tumor cells are negative. Positive internal control represented by small lymphoid cells are present (arrows). D, follicular lymphoma stained for MAL showing that the tumor cells are negative and showing positive internal control in the interfollicular areas. E, T-lymphoblastic lymphoma strongly positive for MAL. F, classical Hodgkin lymphoma showing a negative Reed-Sternberg cell surrounded by positive small lymphocytes.

Back to article page