Figure 1 | Cell Death & Differentiation

Figure 1

From: Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma

Figure 1

Nbk/Bik protein expression in nonmalignant renal tissue and in clear-cell RCC. (a) Left column: normal kidney; right column: RCC cells show loss of Nbk/Bik expression. Magnification: × 200. Paired samples from the same patient are shown. Renal tubules and glomerula lining epithelia show strong Nbk/Bik expression. (b) Box-plot analysis for Nbk/Bik–protein expression in 28 paired samples (tumor and normal tissue from the same patient). Staining index (range 0–300) was calculated as the product of percentage positive cells and staining intensities (0–3). Statistical significance was calculated by Wilcoxon's signed-rank test

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