Figure 1 | Acta Pharmacologica Sinica

Figure 1

From: α1D-Adrenergic receptor insensitivity is associated with alterations in its expression and distribution in cultured vascular myocytes

Figure 1

Differences in contractile and intracellular Ca2+ signal responses to α1-adrenergic receptor activation between the rat thoracic aorta and cultured aortic smooth muscle cells. (A) Stimulating rat aortic rings with PE or high KCl concentration (80 mmol) (indicated with an arrow) induced a tonic force in Ca2+ containing HBSS. Pretreatment of the rings with 1 μmol prazosin for 10 min abolished the effect of PE, but not that of high KCl. (B) PE or Ang II caused a transient aortic contraction in Ca2+-free medium, followed by a tonic constriction upon Ca2+ addition to the medium. (C and D) A [Ca2+]i increase upon stimulation with high KCl (C) or Ang II (D), but not with PE, in cultured aortic VSMCs loaded with fluo4. Numbers for each curve in all panels ranged from 6 to 12 separate experiments.

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