Table 5 Comparison of minimal residual disease markers in primary breast cancer patients with menopausal status and with tumour size and grade of the primary tumour
Menopausal status | Tumour size | Grade | ||||||
---|---|---|---|---|---|---|---|---|
Post | Pre | T1 | T2 | T3 | 1 | 2 | 3 | |
Total circulating free DNA 96-bp (ng ml−1) | ||||||||
Mean | 32.61 | 4.31 | 8.3 | 40.99 | 3.73 | 13.84 | 7.26 | 27.73 |
95% CI | 3.32 to 61.9 | 2.6 to 6.02 | 3.85 to 12.74 | −3.12 to 85.17 | 1.71 to 5.76 | −9.53 to 37.21 | 3.46 to 11.06 | −0.89 to 56.36 |
Median | 1.72 | 1.72 | 1.91 | 1.01 | 1.12 | 0.55 | 1.27 | 1.9 |
Range | 0–2626 | 1–197.6 | 0–439.6 | 0–2626 | 0–45.41 | 0–439.6 | 0–264 | 0–2626 |
No. of samples | 212 | 262 | 254 | 139 | 53 | 38 | 217 | 2 |
P-value | 0.120 | 0.262 | 0.032a | |||||
Circulating free DNA 291-bp (ng ml−1) | ||||||||
Mean | 6.77 | 1.35 | 2.38 | 7.74 | 0.74 | 1.47 | 1.78 | 5.99 |
95% CI | −0.78 to 14.32 | 0.71 to 1.2 | 1.1 to 3.66 | −3.53 to 19.08 | 0.2 to 1.29 | 0.35 to 2.53 | 0.39 to 3.17 | −1.31 to 13.3 |
Median | 0.32 | 0.095 | 0.4 | 0.14 | 0.12 | 0.03 | 0.17 | 0.29 |
Range | 0–785.4 | 0–56 | 0–124.2 | 0–785.4 | 0–13.68 | 0–16.04 | 0–124.2 | 0–785.4 |
No. of samples | 211 | 260 | 251 | 139 | 52 | 36 | 215 | 215 |
P-value | 0.033a | 0.102 | 0.305 | |||||
Disseminated tumour cells(qRT-PCR) b | ||||||||
Mean | 0.087 | 0.088 | 0.08 | 0.09 | 0.104 | 0.08 | 0.08 | 0.1 |
95% CI | 0.07–0.1 | 0.07–0.1 | 0.07–0.1 | 0.07–0.11 | 0.07–0.14 | 0.05–0.1 | 0.07–0.10 | 0.08–0.11 |
Median | 0.05 | 0.06 | 0.05 | 0.05 | 0.05 | 0.04 | 0.05 | 0.05 |
Range | 0–1.12 | 0–1.25 | 0–1.124 | 0–1.02 | 0–1.25 | 0–0.4 | 0–1.25 | 0–1.02 |
No. of samples | 258 | 358 | 256 | 192 | 113 | 49 | 257 | 290 |
P-value | 0.299 | 0.846 | 0.519 | |||||
Disseminated tumour cells (ICC) c | ||||||||
Mean | 0.8 | 0.97 | 0.88 | 0.73 | 1.12 | 0.92 | 0.88 | 0.93 |
95% CI | 0.62–0.97 | 0.78–1.12 | 0.67–1.08 | 0.56–0.89 | 0.66–1.57 | 0.31–1.52 | 0.69–1.07 | 0.72–1.13 |
Median | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Range | 0–11 | 0–15 | 0–12 | 0–7 | 0–15 | 0–12 | 0–9 | 0–15 |
No. of samples | 259 | 351 | 259 | 215 | 87 | 47 | 262 | 284 |
P-value | 0.307 | 0.378 | 0.809 | |||||
Circulating tumour cells d | ||||||||
Mean | 0.37 | 0.46 | 0.17 | 0.59 | 1.03 | 0.35 | 0.15 | 0.68 |
95% CI | −0.09 to 0.83 | 0.14 to 0.79 | 0.09 to 0.25 | −0.06 to 1.25 | −0.34 to 2.4 | 0.01 to 0.68 | 0.07 to 0.23 | 0.12 to 1.24 |
Median | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Range | 0–23 | 0–19 | 0–2 | 0–23 | 0–19 | 0–3 | 0–2 | 0–23 |
No. of samples | 100 | 125 | 120 | 71 | 29 | 23 | 95 | 107 |
P-value | 0.026a | 0.197 | 0.201 |