Table 4 Pharmacokinetic parameters of BPR1J-097 in rats

From: BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML

 

Rat IV (dose: 3.4 mg kg−1)

Compound

T 1/2 (h)

CL (ml min −1 per kg)

V ss (l/kg)

AUC (0–24) (ng ml −1 × h)

BRP1J-097

4.5±1.5

102.4±9.8

15.5±4.8

551±51

  1. Abbreviations: AUC=area under the curve; CL=Clearance; VSS=volume of distribution at the steady state.
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