Figure 1
From: PDK1 inhibition is a novel therapeutic target in multiple myeloma
Expression levels of glycolysis-related genes in primary MM cells obtained from 59 cases. (A) Expression levels of LDHA in purified MM cells. The expression levels vary among the cases. (B) LDHA mRNA expression is positively correlated with serum LDH (rs=0.37, P<0.01). (C) Higher expression of LDHA mRNA is associated with poor overall survival (P<0.01; median survival durations of the cases with low and high LDH expression were 1549 and 408 days, respectively). N=54. (D) Expression levels of glycolytic enzyme genes (LDHA, PDK1 and MYC) in MM and MGUS. The expression levels of all three genes are statistically higher in MM than in MGUS.
