Figure 4 | Cell Death & Differentiation

Figure 4

From: PU.1 supports TRAIL-induced cell death by inhibiting NF-κB-mediated cell survival and inducing DR5 expression

Figure 4

Persistent expression of particular antiapoptotic proteins in TRAIL-treated PU.1-depleted AML cells. (a) XIAP, FLIP (FLIPL and FLIPS), BCL-2, MCL-1 and PU.1 western blot analysis of control and PU.1-depleted NB4, HL60 and MOLM-13 AML cells. Total protein was used as a loading control. One out of two independent experiments is shown. (b–d) XIAP, BCL-2 and MCL-1 quantitative RT-PCR (qPCR) analysis of NB4, HL60 and MOLM-13 cells treated as in (a). *P<0.05

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