Figure 3

Shared linked-haplotype segments as delimited by estimated recombination events plotted against bp position for each of the seven pedigrees linked to chromosome 6p21 region, ordered by maximum by-pedigree LOD score in this region. The three-recombinant boundaries are depicted by the dashed lines. The locations of the maximum by-pedigree LOD scores are shown as horizontal ticks along the plotted regions for each pedigree. The value of the maximum LOD score for each pedigree is given below the plot. The numbers in parentheses indicate the number of affected individuals in each pedigree who share the hypothesized segregating predisposition haplotype, and the total number of affected individuals.