Figure 1

Multipoint linkage analysis results for chromosome 4q in multiplex Chinese families.¹² Depicted are the multipoint heterogeneity LOD scores. α=the estimated proportion of linked families at the peak. The black bar across cytogenetic band 4q32.1 denotes the map position of the PDGF-C locus. The vertical gray bar denotes the 1-LOD interval. Chromosomal marker locations and cytogenetic correlations are according to the Ensemble Database. The asterisk denotes the ___location of D4S192 (142 Mb from 4pter) reported to be significant in previous linkage¹² and association^{10, 11} reports for CL/P in Caucasian and Chilean populations.