Figure 1
From: Identification and characterization of 5′ CCG interruptions in complex DMPK expanded alleles
TP-PCR analysis of 5′ region of the CTG array in members of family C and in a DM1 patient with an uninterrupted DMPK allele as control (bottom panel, EXP). CTG sequence interruptions are visualized as absence of PCR products where the P4-CAG repeated primer cannot bind. Pedigree of family C is added to help to follow the intergenerational dynamics in the pattern of interruptions.
