Figure 7

Apical acidity decreases omeprazole effect on passive Mg²⁺ absorption. Passive Mg²⁺ transport (40 mmol/L concentration gradient) of 200 (A) or 400 ng/ml omeprazole exposed monolayers at various apical pH (D). %maximum passive Mg²⁺ transport - Mg²⁺ concentration curve of 200 (B) or 400 ng/ml omeprazole exposed monolayers at pH 7.4, 6.5, and 5.5 (E). EC₅₀ of the dose - response curve of 200 (C) or 400 ng/ml omeprazole exposed monolayers at pH 7.4, 6.5, and 5.5 (F). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 vs control group. For each data point, n = 6.