Figure 5 | Experimental & Molecular Medicine

Figure 5

From: KR-31543 reduces the production of proinflammatory molecules in human endothelial cells and monocytes and attenuates atherosclerosis in mouse model

Figure 5

Suggested possible mechanism for the anti-atherogenic activity of KR-31543. KR-31543 attenuates the atherosclerotic lesion formation by reducing the production of cytokines and disturbing the adhesion and transmigration of monocytes (red line). The anti-oxidative activity of KR-31543 may also reduce the oxidation of LDL, which can be an additional possible mechanism of its antiatherogenic characteristic (dashed red line).

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