Figure 1 | Experimental & Molecular Medicine

Figure 1

From: Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases

Figure 1

The OAS family in antiviral pathways. Following virus infection of a host cell, viral dsRNA stimulates OAS1, OAS2 and OAS3 and leads to the synthesis of 2′-5′ oligoA and RNase L activation. Activated RNase L cleaves viral and cellular RNA. MDA5 and RIG-I detect cleaved viral RNA, thereby promoting the activation of IRF3 and IRF7. The hOASL binds to RIG-I and enhances the sensitivity of RIG-I signaling through the UBL ___domain, whereas the mOASL1 binds to IRF7 mRNA and inhibits the translation of IRF7.

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