Figure 2 | Experimental & Molecular Medicine

Figure 2

From: Interrupting oral infection of Porphyromonas gingivalis with anti-FimA antibody attenuates bacterial dissemination to the arthritic joint and improves experimental arthritis

Figure 2

Fimbriae play an essential role in Porphyromonas gingivalis (Pg) invasion. (a–c) Bacteria adhesion to the human gingival fibroblast-1 (HGF-1) after infection of Pg with or without pretreatment of anti-FimA antibody (aFimA Ab) is observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), respectively. Scale bar, 100 μm (a) and 1 μm (c). Inserts magnify the small box areas. (b) Quantification of bacteria proportion in SEM images. Statistical analysis was performed using Student’s t-test (n=3, **P<0.01). (d) Immunohistochemical staining of FimA (green) in HGF-1 also shows the attenuation of bacteria adhesion in aFimA Ab-treated Pg. Cell nuclei are stained with 4′,6-diamidino-2-phenylindole (DAPI; blue). Scale bar, 100 μm.

Back to article page