Figure 6 | Experimental & Molecular Medicine

Figure 6

From: Interrupting oral infection of Porphyromonas gingivalis with anti-FimA antibody attenuates bacterial dissemination to the arthritic joint and improves experimental arthritis

Figure 6

Porphyromonas gingivalis (Pg) is involved in synovial inflammation. (a, b) Double immunofluorescence staining of Toll like receptor-2 (TLR2) (a; red) or TLR4 (b; red) and FimA (green) in the joint of collagen-induced arthritis (CIA) mice. Cell nuclei were stained with 4′,6-diamidino-2-phenylindole (DAPI; blue). Scale bar, 100 μm. (c, d) Rheumatoid arthritis synovial fibroblast (RASF) was treated with Pg (c) or crude fimbriae (d) and incubated for various time points. The RNA expression levels of synovial inflammation-related cytokines and proteins were detected by real-time PCR. Statistical analysis was performed using one-way analysis of variance (ANOVA; n=3, *P<0.05 and **P<0.01).

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