Fig. 1

Personal and family history characteristics of genetic susceptibility to coronary artery disease. CAD, coronary artery disease; Close relative, first and/or second degree relative from one lineage; Established risk factors, elevated total and LDL cholesterol, low HDL cholesterol, hypertension, diabetes, smoking; Emerging risk factors, elevated C- reactive protein, fibrinogen, homocysteine, lipoprotein(a), small LDL particles, reduced HDL2b fraction, hyperinsulinemia or other measures of insulin resistance/impaired glucose tolerance, MTHFR C677T, factor V Leiden, and prothrombin G20210A