Abstract
A novel inhibitor of prolyl endopeptidase, the propeptin analog propeptin-2 (C105H130N24O24), missing two amino acid residues from the propeptin C-terminus was isolated from the fermentation broth of propeptin-producing Microbispora sp. SNA-115 grown using a large inoculum. It shows the same enzyme inhibition activity as propeptin against prolyl endopeptidase (Ki=1.5 μM), but its antimicrobial activity against Mycobacterium phlei is more than 100-fold lower.
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Kimura, Ki., Yamazaki, M., Sasaki, N. et al. Novel Propeptin Analog, Propeptin-2, Missing Two Amino Acid Residues from the Propeptin C-Terminus Loses Antibiotic Potency. J Antibiot 60, 519–523 (2007). https://doi.org/10.1038/ja.2007.66
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DOI: https://doi.org/10.1038/ja.2007.66
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