Figure 13: Adaptive remodelling of genomes and genes.
From: Genome sequence of the Brown Norway rat yields insights into mammalian evolution
a, Orthologous regions of rat, human and mouse genomes encoding pheromone-carrier proteins of the lipocalin family (α2u-globulins in rat and major urinary proteins in mouse) shown in brown. Zfp37-like zinc finger genes are shown in blue. Filled arrows represent likely genes, whereas striped arrows represent likely pseudogenes. Gene expansions are bracketed. Arrowhead orientation represents transcriptional direction. Flanking genes 1 and 2 are TSCOT and CTR1, respectively. b, Site-specific KA/KS analysis of rat α2u-globulins. Shown in red are side-chains from codons subject to positive selection. These have been mapped to a ribbon representation of the crystal structure of rat α2u-globulin chain A.
