Figure 16: Selective constraints differ for human disease systems in the rat genome.
From: Genome sequence of the Brown Norway rat yields insights into mammalian evolution
Human disease system categories showing significant differences (P < 0.05) in a non-parametric test (Mann–Whitney–Wilcoxon) comparing KA/KS (human:rat) ratios. P values from two-level tests between genes from one disease system and the remaining genes. (Mean–Mean0)/Std0 values from multi-level tests from 16 categorized disease systems. Negative values (shown in yellow and orange) for neurological (-4.63) and malformation-syndrome (-4.04) categories were observed to be consistent with KA/KS ranges in which purifying selection predominates. Immune, haematological and pulmonary categories show positive values of 4.98, 3.59 and 2.34, respectively (for complete data set and details, see ref. 199).
