Figure 2: Human chromosome 12 evolution.
Numbers above the chromosome indicate the human orthologous chromosome, and numbers to the left of the chromosome refer to the chromosome of the compared organism. Regions orthologous to human chromosome 12 are shown in green. The rodent comparisons to human were performed using Pash28, and the ancestral mammal and chicken are adapted from GRIMM (Genome Rearrangements In Man and Mouse)-Synteny computations presented in ref. 30. On the basis of cytogenetic evidence, a double reciprocal translocation of human chromosomes 12 and 22 occurred after the divergence of prosimian primates, and is present in all anthropoid primates.
