Figure 6: Functional synergy between miR-1204 and MYC secondary to PVT1-MYC fusion.
From: Subgroup-specific structural variation across 1,000 medulloblastoma genomes
a, Quantitative RT–PCR of PVT1-encoded microRNAs confirms upregulation of miR-1204 in PVT1-MYC fusion (+) Group 3 tumours. MYC-balanced/fusion (−), n = 4; MYC-amplified/fusion (−), n = 6; MYC-amplified/fusion (+), n = 8. Error bars represent standard error of the mean (s.e.m.) and reflect variability among samples. b, c, Knockdown of miR-1204 attenuates the proliferative capacity of PVT1-MYC fusion (+) MED8A medulloblastoma cells (b) but has no effect on fusion (−) ONS76 cells (c). Error bars represent the standard deviation (s.d.) of triplicate experiments. CTL, control.
