Extended Data Figure 1: Experimental scheme.
From: Artificial sweeteners induce glucose intolerance by altering the gut microbiota
10-week-old C57Bl/6 male mice were treated with the following dietary regimes. a, Drinking commercially available non-caloric artificial sweeteners (NAS; saccharin, sucralose and aspartame) or glucose, sucrose or water as controls and fed a normal-chow (NC) diet. b, Drinking commercially available saccharin or glucose as control and fed a high-fat diet (HFD). c, Drinking pure saccharin or water and fed HFD. d, As in c, but with outbred Swiss-Webster mice. Glucose tolerance tests, microbiome analysis and supplementation of drinking water with antibiotics were performed on the indicated time points. e, Schematic of faecal transplant experiments.
