Extended Data Figure 4: Metabolic characterization of mice consuming HFD and pure saccharin or water.
From: Artificial sweeteners induce glucose intolerance by altering the gut microbiota
10-week-old C57Bl/6 mice (N = 8) were fed HFD, with or without supplementing drinking water with 0.1 mg ml−1 pure saccharin. After 5 weeks, metabolic parameters were characterized using the PhenoMaster metabolic cages system for 70 h. Light and dark phases are denoted by white and black rectangles on the x-axis, respectively, and grey bars for the dark phase. a, Liquids intake. b, AUC of a. c, Chow consumption. d, AUC of c. e, Respiratory exchange rate (RER). f, AUC of e. g, Physical activity as distance. h, AUC of g. i, Energy expenditure. The metabolic cages characterization was repeated twice.
