Extended Data Figure 4: Characterization of the FIP1L1 enhancer.
From: Insulator dysfunction and oncogene activation in IDH mutant gliomas
a, H3K27ac ChIP-seq track for GSC6 gliomaspheres reveals strong enrichment over the FIP1L1 enhancer. CTCF ChIP-seq track reveals ___location of the boundary element insulator (as in Fig. 3a). FIP1L1 enhancer (i) and promoter (ii) are indicated. b, H3K27ac ChIP-seq tracks for IDH mutant and wild-type gliomaspheres and glioma specimens reveal enrichment over the FIP1L1 enhancer. c, ChIP-seq tracks for glioma master transcription factors and other histone modifications support the enhancer identity of the element (H3K27ac, H3K4me1, SOX2, OLIG2; lacks H3K4me3, lacks H3K27me3). By contrast, the FIP1L1 promoter has a distinct ‘promoter-like’ chromatin state.
