Extended Data Figure 4: Comparison between the full-length GCGR crystal structure and previously published structure and model.
From: Structure of the full-length glucagon class B G-protein-coupled receptor
a, b, Comparison between the GCGR–mAb1 complex structure and the previously published model of the GCGR–glucagon complex7. Only the receptors in the GCGR–mAb1 complex structure and the model are shown in cartoon representation and coloured in blue and yellow, respectively. The ECDs are also shown in surface representation. The stalk in the full-length GCGR structure is in green, and the stalk in the model is coloured magenta. a, Side view; b, top view. c, Comparison between the full-length GCGR structure and crystal structure of the ECD of GLP-1R bound to its endogenous ligand GLP-1. Structural superimposition shows spatial clashes between ECL1 and helix II of GCGR and GLP-1. The receptor in the full-length GCGR structure is shown as blue cartoon, and the ligand NNC0640 is displayed as magenta spheres. The complex structure of the ECD of GLP-1R bound to GLP-1 (PDB ID: 3IOL) is shown in cartoon representation. The ECD of GLP-1R is coloured green, and GLP-1 is in red.
