Extended Data Figure 5: Effects of sample size and assayed tissues on cis-eGene discovery.
From: Genetic effects on gene expression across human tissues
a, Number of significant cis-eGenes at 5% FDR (y-axis) discovered in 44 GTEx tissues versus sample size (x-axis). b, Number of significant eGenes at FDR 5% (y-axis) discovered in nine GTEx tissues each subsampled to various sizes where possible (n = 70, 100, 125, 150, 175, 200, 225, 250, 275, 300, 325, and 350; x-axis). We computed the number of cis-eGenes at each subsample size (circles connected by lines). We also plotted the number of cis-eGenes discovered with no subsampling of donors (diamonds). c, Number of significant cis-eGenes at FDR 5% (y-axis) as a function of sample size and number of tissues assayed (x-axis). Each tissue was subsampled to 70, 100, 150, 200, and 250 donors, and a forward search was used to assess sequential combinations of tissues that maximize the total number of unique cis-eGenes discovered.
