Extended Data Figure 11: Characterization of GRR gene regulation by PRC1 and 5mC in PGCs and mouse ES cells. | Nature

Extended Data Figure 11: Characterization of GRR gene regulation by PRC1 and 5mC in PGCs and mouse ES cells.

From: Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

Extended Data Figure 11

a, Overlap between GRR genes and genes significantly upregulated in E11.5 and/or E12.5 PRC1 CKO PGCs compared with wild-type26. P values based on hypergeometric test. b, Representative western blot showing H2Aub and H2A levels in wild-type or DNMT TKO mouse ES cells after 6 h DMSO treatment, and wild-type or DNMT TKO mouse ES cells after 6 h PRT4165 treatment. c, Classification of GRR genes on the basis of their dependency for 5mC and/or PRC1 reprogramming in mouse ES cells (see Methods).

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