Extended Data Figure 12: Model.
From: Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte
The timely and efficient activation of GRR genes, involved in the transition from PGC to gonocyte and the correct progression of gametogenesis, requires interactions between promoter CpG density, the initiation of global DNA demethylation, TET1 recruitment, and removal of PRC1-mediated repression. Both DNA demethylation-dependent (safeguarding against aberrant residual and/or de novo promoter DNA methylation) and -independent (such as the potential recruitment of OGT or other transcriptional activators to gene promoters22,28) functions of TET1 are important for GRR gene activation.
