Supplementary Figure 8: ASPP2 expression correlates with EMT status in human HCC, and the ASPP2 expression pattern in breast cancer is also shown. | Nature Cell Biology

Supplementary Figure 8: ASPP2 expression correlates with EMT status in human HCC, and the ASPP2 expression pattern in breast cancer is also shown.

From: ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1

Supplementary Figure 8

(a) The relationships between ASPP2 expression and protein expression of β-catenin, ZEB1 and E-cadherin were analysed (Mann–Whitney U-test: P < 0.001). Nuclear β-catenin negative n = 133 and nuclear β-catenin positive n = 40; nuclear ZEB1 negative n = 126 and nuclear ZEB1 positive n = 53; junctional E-cadherin positive n = 69 and junctional E-cadherin negative n = 117. Spread of data denoted by box-and-whisker plot, the central box represents the value from the lower to upper quartile (25th–75th percentile). The middle line represents the median. The whisker ends 1 and 99 percentiles. (b) Representative ASPP2 staining pattern (High or Low ASPP2) in 275 human breast cancer tissue microarray cores. Scale bar: 50 μm. For source data, see Supplementary Table 1.

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