Figure 6: Summary showing consequences of ultraviolet-cone loss and replacement in shaping the connectivity of H3 HCs from development to regeneration.
Schematic of H3 HC connectivity patterns during development and regeneration. Colour-filled circles represent cones (purple, ultraviolet cone; cyan, blue cone; green, green cone; and red, red cone) contacted by an individual H3 HC (cell body of HC denoted by open circle). Dark-purple-coloured circles represent original ultraviolet cones; light purple indicate regenerated ultraviolet population. Our previous study suggests that transmission from ultraviolet cones suppresses H3 HC synaptogenesis with blue cones during development8. Here we propose that this ‘brake’ signal persists after ultraviolet-cone loss for a defined period of time (1), but is lost or not replenished if there is no regeneration of ultraviolet cones (2) or regeneration is delayed (3). UV, ultraviolet.
