Figure 1: Manhattan and Q–Q plots for genome-wide association analysis of both continuous and extreme chronotype.

Manhattan plots (a,c). Red line is genome-wide significant (5 × 10−8) and blue line is suggestive (1 × 10−6). Q–Q plots (b,d). Nearest gene name is annotated. Heritability estimates were calculated using BOLT-REML and lambda inflation values using GenABEL in R.