Figure 3: Cortical brain activity in anticipation of large versus small gains for control subjects (n=72) versus problematic drug users (n=72). | Nature Communications

Figure 3: Cortical brain activity in anticipation of large versus small gains for control subjects (n=72) versus problematic drug users (n=72).

From: Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents

Figure 3

The PDU group showed decreased activation in the right dorsolateral prefrontal cortex (for VOI-based statistics, see Table 2). Overlaid on a mean structural magnetic resonance scan, activation display threshold is P<0.005 (uncorrected, t-test). Highlighted areas indicate volumes of interest in the dorsolateral prefrontal cortex (PFC foci: ±35, 36, 32). Error bars=±s.e.m. *Significant at threshold of P<0.0083 uncorrected or P<0.05 corrected (n=144, t-test).

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