Figure 2: Analysis of PRS for schizophrenia in a target sample of 10,032 ALS cases and 16,627 healthy controls.
From: Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
P-value thresholds (PT) for schizophrenia SNPs are shown on the x axis, where the number of SNPs increases with a more lenient PT. Δ Explained variances (Nagelkerke R2, shown as a %) of a generalized linear model including schizophrenia-based PRS versus a baseline model without polygenic scores (blue bars) are shown for each PT. −Log10 P-values of Δ explained variance per PT (red dots) represent P-values from the binomial logistic regression of ALS phenotype on PRS, accounting for LD (Supplementary Table 4) and including sex and significant principal components as covariates (Supplementary Fig. 2). Values are provided in Supplementary Table 5.
