Figure 3: Odds ratio for ALS by PRS deciles for schizophrenia.
From: Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
The figure applies to schizophrenia P-value threshold (PT)=0.2. The PRS for this threshold were converted to ten deciles containing near identical numbers of individuals. Decile 1 contained the lowest scores and decile 10 contained the highest scores, where decile 1 was the reference and deciles 2–10 were dummy variables to contrast to decile 1 for OR calculation. The case:control ratio per decile is indicated with grey bars. Error bars indicate 95% confidence intervals. Significant differences from decile 1 were determined by logistic regression of ALS phenotype on PRS decile, including sex and principal components as covariates and are indicated by *P<0.05 or ***P<0.001.
