Figure 7: CTIF is enriched in the Lewy bodies of PD.
From: Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex
(a) Immunohistochemistry for CTIF and α-synuclein in the cerebellar molecular layer of PD patients. A normal subject was examined as a control. Nuclei were visualized with haematoxylin and eosin (H&E) counterstain (haematoxylin-positive nuclei, purple). Right panels are higher-magnification views of the left panels (dashed boxes). Black arrows indicate Lewy body-like structure. Scale bar, 50 μm (left), 20 μm (right). ml, molecular layer; gcl, granular cell layer. (b) Double-immunofluorescent histochemistry for CTIF (green) and α-synuclein (red) in the cerebellar molecular layer of PD patients. Nuclei (blue) were visualized using DAPI. White arrows indicate double-labelled cells. Scale bar, 10 μm. (c) Proposed model for CED-mediated protein surveillance and CT inhibition. The details are described in the Discussion section.
