Table 4 Association of three SNPs with severe acne analysed by gender stratification in Chinese Han population.

From: Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne

CHR

SNP

Gene

Male versus control

Female versus control

Heterogeneity*

OR for heterogeneity*

   

P -value †

OR (95% CI)

P -value †

OR (95% CI)

  

1q24.2

rs7531806

SELL

6.57E-06

1.19 (1.10–1.28)

3.91E-03

1.18 (1.05–1.31)

0.843

1.01 (0.90–1.14)

11p11.2

rs747650

DDB2

2.53E-08

1.25 (1.16–1.35)

5.75E-04

1.22 (1.09–1.37)

0.712

1.02 (0.90–1.16)

11p11.2

rs1060573

DDB2

5.22E-08

1.24 (1.15–1.34)

1.18E-03

1.21 (1.08–1.35)

0.646

1.03 (0.91–1.16)

  1. *P-values and odds ratios were calculated using chi-square (χ2) test from the difference in the odds ratios between males and females.
  2. †P-values were combined across discovery and replication stage and generated using logistic regression.
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