Figure 2: X chromsome inactivation distinguishes male and female samples. | Nature Communications

Figure 2: X chromsome inactivation distinguishes male and female samples.

From: Systematic chromatin state comparison of epigenomes associated with diverse properties including sex and tissue type

Figure 2

Comparison of male and female epigenomes identifies (a) 536 distinguishing features that are associated with 369 genes and all 15 chromatin states, where (b) 264 of the 369 genes are located on the X chromosome. (c) 124 of the identified X chromsome genes are mainly quiescent in male samples but weakly repressed or heterochromatic in female cell types (mostly in cluster B), while 56 genes are transcribed in female and male samples (mostly autosomal genes in cluster A), shown here by the most abundant chromatin state for these genes. (d) Expression data for these genes (when available) confirm similar expression levels between male and female samples, as suggested by the chromatin state annotations.

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