Supplementary Figure 5: Cancer type–specific enhancer activity of the super-enhancer region.
From: Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers
(a) ChIP-seq profile of H3K27ac at the MYC locus. No enrichment of H3K27ac is detectable at the MYC-LASE region for HEK293 cells. (b) Luciferase reporter assay (n = 3) of the five constituent enhancers, e1–e5, in A549 lung adenocarcinoma cells and HEK293 cells. The P value is derived from a t test: **P ≤ 0.01, ***P ≤ 0.001.
