Supplementary Figure 12: T cell subtype HiChIP specificity of autoimmune disease–associated SNPs. | Nature Genetics

Supplementary Figure 12: T cell subtype HiChIP specificity of autoimmune disease–associated SNPs.

From: Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements

Supplementary Figure 12

(a) H3K27ac HiChIP signal bias in T cell subsets for PICS SNP–TSS pairs grouped by each SNP's presence in cell-type-specific or shared H3K27ac ChIP peaks up to 8 kb away. (b) H3K27ac HiChIP signal bias in T cell subsets for PICS SNP–TSS pairs grouped by each SNP's presence in cell-type-specific or shared H3K27ac ChIP peaks up to 2.5 kb away. (c) H3K27ac HiChIP signal bias in GM, K562, and My-La cell lines for PICS SNP–TSS pairs grouped by each SNP's presence in T cell subset-specific or shared H3K27ac ChIP peaks up to 8 kb away. (d) H3K27ac HiChIP signal bias in T cell subsets for GRASP SNP–TSS pairs grouped by each SNP's presence in cell-type-specific or shared H3K27ac ChIP peaks up to 2.5 kb away. (e) Left, average number of HiChIP gene targets for non-genic autoimmune disease and non-immune SNPs. Middle, quantification of SNP HiChIP gene targets in autoimmune disease. Right, quantification of promoters skipped before a SNP reaches its gene target.

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