Figure 1
Effects of MOR agonists, U69,593, and cocaine on intracranial self-stimulation (ICSS) in h/mOPRM1-118AA and 118GG mice. (a) Average baseline rate–frequency curves for h/mOPRM1-118AA (black circles; n=49) and 118GG mice (yellow triangles; n=48) performing ICSS. (b and c) Effects of cocaine (1–10 mg/kg i.p.), U69,593 (0.01–0.1 mg/kg i.p.), fentanyl (FENT; 0.01–0.3 mg/kg s.c.), buprenorphine (BUP; 0.01–10 mg/kg i.p.), oxycodone (OXY; 0.01–10 mg/kg i.p.), morphine (MS; 1.0–10 mg/kg i.p.), and hydrocodone (HYD; 1.0–10 mg/kg i.p.) on BSR threshold in h/mOPRM1-118AA (black circles; n=10, 11, 7, 8, 7, 10, and 8, respectively) and 118GG mice (yellow triangles; n=11, 12, 10, 10, 8, 11, and 12, respectively). Values represent mean±SEM. *p<0.05 vs h/mOPRM1-118AA; #p<0.05 vs vehicle.
