Common Transactivation Motif 9aaTAD recruits multiple general co-activatorsTAF9, MED15, CBP and p300

More than 2000 transcription factors are involved in the human gene regulation to provide cellular function and development. Transactivation ___domain, TAD, mediates the interaction of transcription factors with general transcriptional co-activators such as TAF9, MED15, CBP and p300. Recently reported NMR-data for interactions of these co-activators with transcription factors reveal tightly binding of KIX and TAZ domains to common 9aaTAD motif. Nine-amino-acid Trans-Activation Domain, 9aaTAD, defines a transactivation ___domain common to a large super-family of eukaryotic transcription factors represented in yeast by Gal4, Oaf1, Pdr1, Rtg3, Pho4, Gln3, Gcn4 and in mammals by p53, E2A, NFAT, NFkB, HSF1, NF-IL6, MLL, EBNA2, VP16. The 9aaTAD family was derived from the transcription factor Oaf1 and its close orthologs Gal4, Pdr1, Leu3, Tea1 and Cha4.