Abstract
A new approach to design a dynamic model of genes with multiple autonomous regulatory modules by evolution in silico is proposed. The approach is based on Genetic Algorithms, with new crossover operators especially designed for these purposes. The approach exploits the subbasin-portal architecture of the fitness functions suitable for this kind of evolutionary modeling. The effectiveness of the approach is demonstrated on a series of benchmark tests.
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Spirov, A., Holloway, D. Design of a dynamic model of genes with multiple autonomous regulatory modules by evolution in silico. Nat Prec (2009). https://doi.org/10.1038/npre.2009.3913.1
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DOI: https://doi.org/10.1038/npre.2009.3913.1
