Fig. 5: Rapamycin treatment attenuates RHEB p.Y35L mutation-induced abnormal EEG and seizures.
From: A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II
a One-and-half-month-old mice with embryonic expression of the p.Y35L RHEB plasmid were first recorded for EEG, treated with rapamycin at 10 mg/kg for 11 days, and recorded for EEG again. The interictal spike frequency (b) and amplitude (c) of EEG in a were quantified for comparison. Data are presented as the mean ± s.e.m, n = 3, *P < 0.05, **P < 0.01 (Student’s t-test). d The seizure frequency in p.Y35L RHEB-carrying mice was recorded over a 3-h-long period before and after rapamycin treatment for comparison. Data are presented as the mean ± s.e.m, n = 3, **P < 0.01 (Student’s t-test)
