Table 3 Substrates of ROCK1 involved in cytoskeletal regulation in mitosis and metastasis.
From: Mitotic protein kinase-driven crosstalk of machineries for mitosis and metastasis
Mitosis | |||
|---|---|---|---|
Substrate | Phosphorylation sites | Mitotic function | Reference |
LIMK1 | Thr508 | Phosphorylation of cofilin at Ser3 and its inactivation, resulting in stabilization of cortical actin networks | |
Vimentin | Ser71 | Turnover of vimentin at the cleavage furrow | |
MLC | Thr18, Ser19 | Actomyosin contraction | |
MYPT1 | Thr696, Thr853 | Actomyosin contraction | |
Metastasis | |||
|---|---|---|---|
Substrate | Phosphorylation sites | Metastatic function | Reference |
MLC | Thr18, Ser19 | Actomyosin contraction | |
LIMK1 | Thr508 | Inhibition of actin depolymerization | |
PTEN | N.D. | Activation of PI3K/AKT and polymerization of actin filaments for protrusion | |
c-Myc | Thr58, Ser62 | Transcriptional stabilization and activation of c-Myc for metastatic regulation | |
