Fig. 3: Schemes of direct sequencing technologies. | Experimental & Molecular Medicine

Fig. 3: Schemes of direct sequencing technologies.

From: Detection technologies for RNA modifications

Fig. 3

a Detection of A-to-I editing sites by detecting A-to-G mismatches between genomic DNA and RNA sequencing (RNA-seq) data from the same individuals. b Detection of modified nucleotides by utilizing demethylase treatment, altered RT conditions, engineered reverse transcriptase, or modified dNTPs to generate distinct RT signatures at modified sites between treated and untreated samples. Modifications that can be detected by the corresponding approaches are listed below.

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