Fig. 2: Plasma cell subsets of MM in scRNA-seq. | Experimental & Molecular Medicine

Fig. 2: Plasma cell subsets of MM in scRNA-seq.

From: Single-cell analysis of multiple myelomas refines the molecular features of bortezomib treatment responsiveness

Fig. 2

a Genome-wide heatmap displaying CNA profiles of plasma cells from 18 MM patients (left: ORs; right: SORs). CNAs were inferred from the scRNA-seq data using the inferCNV R package. Red and blue indicate copy number gains and losses, respectively. The X-axis shows chromosomes in numerical order. Plasma cells from different MM patients are indicated as different color bars on the bottom of the heatmap. b–d UMAP plot colored based on plasma cell subsets (b), clinical groups (c), and patients (d). e Bar plot representing the number of cells per plasma cell subset. Each bar is color-coded according to clinical groups as shown in (c). The names above the bars correspond to the individual cases, with the majority of cells in each cluster. f Bar plot representing plasma cell composition in individual ORs and SORs. g Violin plots present the expression of common MM driver genes in 20 healthy donors (alphabets “A” to “W”) and 18 MM patients (numbers “MM042” to “MM233”). Each violin plot is color-coded according to the clinical groups as shown in (c). The gray dotted line represents the average expression in healthy donors.

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