Fig. 6: Pim1-deficient mice display greater susceptibility to poly (I:C)-induced death.
From: Pim1 promotes IFN-β production by interacting with IRF3
WT and Pim1−/− mice were challenged with poly (I:C) (2.5 mg kg−1) plus D-galactosamine (1 g kg−1). a Animal survival was monitored every 6 h for 5 d (WT, n = 13; Pim1−/−, n = 14). b, IFN-β and IL-6 levels in the serum of the mice 6 h after injection (WT, n = 11; Pim1−/−, n = 13). The data are presented as the mean ± sd values and are from at least two independent experiments with similar results. *p < 0.05 as determined by using the log-rank (Mantel‒Cox) test; **p < 0.01 as determined by two-tailed Student’s t test.
