Fig. 5: TGF-β inhibition improved hematopoietic recovery by repairing BM EC damage in AA mice.
From: TGF-β inhibition restores hematopoiesis and immune balance via bone marrow EPCs in aplastic anemia
a–d, Counts of hemoglobin (a), red blood cells (RBCs) (b), platelets (c) and white blood cells (WBCs) (d) in all the mouse groups. e–h, The counts of myeloid progenitor cells (MPCs) (lineage−cKIT+SCA1−) (e), KLS (cKIT+lineage−SCA1+) cells (f), HSCs (g) and multipotent progenitors (MPPs) (lineage−SCA1+cKIT+CD150−CD48−) (h) per million cells within murine BM. i, The hematopoietic volume in murine BM. j, The frequencies of myeloid cells (CD45+Gr-1+), B cells (CD45+CD3−B220+) and T cells (CD45+CD3+B220−) among CD45+ cells in murine BM. The data are presented as the mean ± s.e.m. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).
